A. Ai Yamamoto, Ph.D.
The acclaimed Columbia neuroscientist, a leading researcher in autophagy–or protein trafficking–in Huntington’s, has turned her talents to ALS. Project ALS recruited Dr. Yamamoto and Noah Depoure, Ph.D., a quantitative biochemist at Cornell, to characterize protein aggregation in ALS. One year in to the study, Yamamoto has identified a possible strategy for augmenting protein turnover in ALS.
Motor neurons project out to the muscles in our limbs to drive muscle contraction, allowing us to speak, breathe, and move. These cells are housed