2025 Holiday Season

Every dollar you give this holiday season helps drive progress across the Project ALS Therapeutics Core — a collaboration of leading scientists working to stop ALS from every angle.

Accelerate ALS Research

AI for Diagnosis & Treatment

No two cases of ALS are alike, but AI is helping us find patterns. Project ALS researchers study skin cells to uncover “clusters” of similar cases.
Your gift helps expand this work and bring us closer to personalized ALS treatments.

Be a Catalyst for Discovery

Antibody Therapeutics for ALS

At the Project ALS Therapeutics Core, researchers develop antibodies with extraordinary precision. In the lab, we’ve long used them to identify different cell types and study how ALS affects them. Now, we’re exploring their potential as therapies, designed to target and remove the protein aggregates that damage motor neurons.
Your gift helps turn tools that once helped us study ALS into potential treatments.

Support Critical Research

Advancing Kleinerpaullone

Project ALS researchers have optimized kleinerpaullone, a brain-penetrant compound targeting two key ALS drivers, helping protect motor neurons and slow disease in preclinical studies.
Your gift helps expand safety testing and move this potential therapy toward the clinic.

Help Turn Science Into Treatments

Strengthening Motor Neurons

Researchers are finding ways to keep motor neurons strong. In mouse studies, this work has improved nerve function and reduced harmful protein buildup.
Your gift helps test whether “rejuvenation factors” can protect vulnerable neurons, bringing us closer to therapies that preserve strength and movement.

Fuel the Fight Against ALS

Knowing Project ALS does preclinical testing on drug candidates before they go to clinical trial gives me hope that they will be successful. Their passion and transparency with their research gets me excited for the future.

Project ALS approaches problems in the same way I did as an engineer: tactically, efficiently, and believing in a solution. Take that mentality, plus the passion and love that fuels them, and you've got an unstoppable force for good for those of us with ALS. Progress is inevitable with their formula; they’ve already proven it.

You care about us as people. And I think that for any company, entity, whoever, if you’re going to find drugs that work and eventually find cures, you need to care about the people, first and foremost.