THE PROJECT ALS MISSION
Project ALS identifies and funds the most promising scientific research that will lead to the first effective treatments and a cure for ALS. We recruit the world’s best scientists and doctors to work together—rationally and aggressively—to develop a better understanding of the ALS disease process and, in parallel, better therapeutic strategies.
Read about the latest updates in ALS research, and see the Project ALS research philosophy – something we’re proud to say has accelerated the pace of research.
WHAT'S NEW WITH PROJECT ALS
Viruses for Good, Not Evil: Tools for ALS Therapy Delivery
Motor neurons project out to the muscles in our limbs to drive muscle contraction, allowing us to speak, breathe, and move. These cells are housed in the spinal cord and brain. When someone has ALS, their motor neurons become unhealthy and die, making these cells the primary target for treating ALS. However, because motor neurons are located in the spinal cord and brain, they are difficult to apply therapies to
NextGen ALS: A Weber Family Initiative
In 2020, Cathy and Richard called Project ALS after hearing about the development of a novel antisense oligonucleotide (ASO) therapy for people living with FUS ALS. So was born NextGen ALS, a Weber family initiative in collaboration with Project ALS that is committed to raising funds for targeted research toward treatments and cures for genetic forms of ALS.
Valerie the Disruptor
Project ALS co-founder Valerie Estess sat down with Charles River to talk about how Project ALS is disrupting the norm in order to bring the first treatments and a cure to people with ALS as quickly as possible. Valerie talks about the development of jacifusen, now in PII/PIII international trial thanks to an incredible Project ALS-led team—which included partners like Charles River—to treat a genetic form of ALS. The unique,